Name: Dr. Fauci has a stunningly simple way to explain how Johnson & Johnson's COVID-19 vaccine differs from Pfizer's and Moderna's shots
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Dr. Fauci has a stunningly simple way to explain how Johnson & Johnson's COVID-19 vaccine differs from Pfizer's and Moderna's shots

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The word "Insider".Two crossed lines that form an 'X'. It indicates a way to close an interaction, or dismiss a notification.The US now has : two mRNA options from Pfizer and Moderna, and one .While it's true that Moderna's and Pfizer's shots were more effective overall than J&J's in trials, experts have stressed that all these vaccines share two very important statistics: zero hospitalizations and zero deaths among fully vaccinated trial participants.When asked which shot might provide people the best long-term protection from infection, including protection against worrisome like B.1.351, , a leading virus expert, told Insider on Monday, "There's little that can be said, for now."We do already know there are key differences in the way these two types of vaccines work.During a White House briefing on Monday, President Joe Biden's chief medical advisor, Dr. Anthony Fauci, explained exactly how each shot takes effect.Pfizer's and Moderna's vaccines train the body to fight COVID-19 by injecting mRNA, or messenger RNA, into a person's deltoid, the rounded muscle that hugs the upper arm and shoulder."The mRNA that's injected into the muscle codes for the spike protein," Fauci said.The coronavirus' spike protein is what allows the virus to latch on to and invade our cells. But the mRNA vaccines train our bodies to say, immunologically, "Not so fast.""The body sees that [protein] and makes an immune response against that, giving you the protection that has been shown with both of the mRNA vaccines," Fauci added.J&J's shot injects viral DNA, not mRNA. This is a key reason J&J's vaccine is so much easier to manufacture and to store in the fridge: The DNA inside is not as fragile as the single-stranded mRNA in Pfizer's and Moderna's shots.That DNA is encapsulated in a "harmless, non-replication-competent virus," Fauci said.That adenovirus, called Ad26, is a common cold virus , so it can't get you sick.Once the vaccine is injected into a person's arm, the virus injects its DNA into cells, where it's copied into messenger RNA. That mRNA then codes for coronavirus spike proteins in the same way as Pfizer's or Moderna's shots.The "ultimate end game" of adenovirus and mRNA COVID-19 vaccines is the same, Fauci said."Both of the vaccines ultimately result in a spike protein in the right conformation that gives the body the opportunity to feel that this is the actual virus that it's seeing," he said.To be clear, he added, it's not the virus, "it's the protein."That prepares a vaccinated person's body to fight off a COVID-19 infection if the person comes into contact with the virus.Both the mRNA and the adenovirus vaccines appear to prevent the most severe COVID-19 infections very well: Pfizer's and Moderna's two-shot courses were more than 94% effective in their trials, while J&J's was 85% effective in preventing severe disease and death.Adenovirus vaccines like J&J's might give people a more robust form of immunity against viral variants, with . (mRNA vaccines may provide only more narrow antibody protection.) But as more people get vaccinated and variants continue to spread.Either way, in order to blunt the spread of the virus across the US and to help end the pandemic.Something is loading.Get the latest from Business Insider Intelligence on how COVID-19 is affecting industries.NewsletterKnow the latest in healthcare industry with our Healthcare newsletter.Something is loading.It indicates an expandable section or menu, or sometimes previous / next navigation options.Two crossed lines that form an 'X'. It indicates a way to close an interaction, or dismiss a notification.

The word "Insider".Two crossed lines that form an 'X'. It indicates a way to close an interaction, or dismiss a notification.The US now has : two mRNA options from Pfizer and Moderna, and one .While it's true that Moderna's and Pfizer's shots were more effective overall than J&J's in trials, experts have stressed that all these vaccines share two very important statistics: zero hospitalizations and zero deaths among fully vaccinated trial participants.When asked which shot might provide people the best long-term protection from infection, including protection against worrisome like B.1.351,...

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Hilary Brueck

Business Insider is an American financial and business news website founded in 2009 and owned by the German publishing house Axel Springer. It operates 14 national editions and an international edition. Several national editions are published in local languages.

Dr. Fauci has a stunningly simple way to explain how Johnson & Johnson's COVID-19 vaccine differs from Pfizer's and Moderna's shots

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Dr. Fauci has a stunningly simple way to explain how Johnson & Johnson's COVID-19 vaccine differs from Pfizer's and Moderna's shots

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