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Covid-19: what treatments are being investigated?

Covid-19: what treatments are being investigated?

Covid-19: what...Covid-19: what treatments are being investigated?;The BMJWith no current specific treatment for covid-19, the race is on to develop or repurpose drugs to help end the epidemic. The World Health Organization has now launched the SOLIDARITY trial to investigate four potential treatments: remdesivir, chloroquine/hydroxychloroquine; lopinavir and ritonavir; and lopinavir and ritonavir plus interferon-β. The trial will not be double blind, as WHO said it needed to find a balance between gold standard research practice and speed, but it will include thousands of patients from...

March 26, 2020
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Paul Garner: For 7 weeks I have been through a roller coaster of ill health, extreme emotions, and utter exhaustion - The BMJ

Paul Garner: For 7 weeks I have been through a roller coaster of ill health, extreme emotions, and utter exhaustion - The BMJ

Paul Garner is Professor at the Liverpool School of Tropical Medicine. He is Director of the Centre for Evidence Synthesis in Global Health and Co-ordinating Editor of the Cochrane Infectious Diseases Group.Twitter:Competing interests: None declaredBMJ Opinion provides comment and opinion written by The BMJ's international community of readers, authors, and editors.We welcome submissions for consideration. Your article should be clear, compelling, and appeal to our international readership of doctors and other health professionals. The best pieces make a single topical point. They are well...

May 5, 2020
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Covid-19: “Staggering number” of extra deaths in community is not explained by covid-19

Covid-19: “Staggering number” of extra deaths in community is not explained by covid-19

Covid-19: “Staggering...Covid-19: “Staggering number” of extra deaths in community is not explained by covid-19;LondonOnly a third of the excess deaths seen in the community in England and Wales can be explained by covid-19, new data have shown.The Office for National Statistics (ONS) data, which cover deaths in hospitals, care homes, private homes, hospices, and elsewhere, show that 6035 people died as a result of suspected or confirmed covid-19 infection in England and Wales in the week ending 1 May 2020 (where deaths were registered up to 9 May), a decline of 2202 from the previous...

May 13, 2020
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Face masks for the public during the covid-19 crisis

Face masks for the public during the covid-19 crisis

Face masks for the...Face masks for the public during the covid-19 crisis;, , , , 1Nuffield Department of Primary Care Health Sciences, University of Oxford2Neonatal Department, University Hospital of Zurich, Switzerland3University of Zurich, Zurich, Switzerland4Institute for Advanced Studies, Vienna, Austria5London School of Economics, London, UK6University of Edinburgh, UK7University of Glasgow, UKCorrespondence to: T Greenhalgh Trisha Greenhalgh and colleagues argue that it is time to apply the precautionary principleThe precautionary principle is, according to Wikipedia, “a strategy for...

April 9, 2020
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Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal

Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal

Prediction models for...Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal;, , , , , , , , , , , , , , , 1Department of Epidemiology, CAPHRI Care and Public Health Research Institute, Maastricht University, Peter Debyeplein 1, 6229 HA Maastricht, Netherlands2Department of Development and Regeneration, KU Leuven, Leuven, Belgium3Department of Biomedical Data Sciences, Leiden University Medical Centre, Leiden, Netherlands4Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht University,...

April 7, 2020
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COVID-19 ’ICU’ risk – 20-fold greater in the Vitamin D Deficient. BAME, African Americans, the Older, Institutionalised and Obese, are at greatest risk. Sun and ‘D’-supplementation – Game-changers? Research urgently required.

COVID-19 ’ICU’ risk – 20-fold greater in the Vitamin D Deficient. BAME, African Americans, the Older, Institutionalised and Obese, are at greatest risk. Sun and ‘D’-supplementation – Game-changers? Research urgently required.

Is ethnicity linked to...COVID-19 ’ICU’ risk – 20-fold greater in the Vitamin D Deficient. BAME, African Americans, the Older, Institutionalised and Obese, are at greatest risk. Sun and ‘D’-supplementation – Game-changers? Research urgently required.;Dear EditorCOVID-19 (Coronavirus) mortality disproportionately impacts BAME (Black, Asian and Minority Ethnic) UK individuals, African Americans, Swedish Somalis,[1] and the institutionalised; particularly care-home residents. COVID-19 severity and mortality, appear related to vitamin D deficiency, [2 -12] helping explain higher COVID-19...

May 19, 2020
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Incidence, clinical outcomes, and transmission dynamics of severe coronavirus disease 2019 in California and Washington: prospective cohort study

Incidence, clinical outcomes, and transmission dynamics of severe coronavirus disease 2019 in California and Washington: prospective cohort study

Incidence, clinical...Incidence, clinical outcomes, and transmission dynamics of severe coronavirus disease 2019 in California and Washington: prospective cohort study;, , , , , , , , , , , , , 1Division of Epidemiology and Biostatistics, School of Public Health, University of California, Berkeley, Berkeley, CA, 94720, USA2Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA, USA3Center for Computational Biology, College of Engineering, University of California, Berkeley, Berkeley, CA, USA4Division of Research, Kaiser...

May 22, 2020
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Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study

Features of 20 133 UK...Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study;, , , , , , , , , , , , , , , , , , , , , , , , on behalf of the ISARIC4C investigators1Centre for Medical Informatics, Usher Institute, University of Edinburgh, Edinburgh, UK2Intensive Care Unit, Royal Infirmary Edinburgh, Edinburgh, UK3Institute of Microbiology and Infection, University of Birmingham, Birmingham, UK4National Institute of Health Research (NIHR) Health Protection Research Unit in Emerging and...

May 22, 2020
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COVID-19: in the footsteps of Ernest Shackleton

COVID-19: in the footsteps of Ernest Shackleton

Article TextBrief communicationCOVID-19: in the footsteps of Ernest ShackletonWe describe what we believe is the first instance of complete COVID-19 testing of all passengers and crew on an isolated cruise ship during the current COVID-19 pandemic. Of the 217 passengers and crew on board, 128 tested positive for COVID-19 on reverse transcription–PCR (59%). Of the COVID-19-positive patients, 19% (24) were symptomatic; 6.2% (8) required medical evacuation; 3.1% (4) were intubated and ventilated; and the mortality was 0.8% (1). The majority of COVID-19-positive patients were asymptomatic (81%,...

May 27, 2020
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Comparison of dietary macronutrient patterns of 14 popular named dietary programmes for weight and cardiovascular risk factor reduction in adults: systematic review and network meta-analysis of randomised trials

Comparison of dietary macronutrient patterns of 14 popular named dietary programmes for weight and cardiovascular risk factor reduction in adults: systematic review and network meta-analysis of randomised trials

Comparison of dietary...Comparison of dietary macronutrient patterns of 14 popular named dietary programmes for weight and cardiovascular risk factor reduction in adults: systematic review and network meta-analysis of randomised trials;, , , , , , , , , , , , , , , , , , , 1Evidence Based Social Science Research Centre, School of Public Health, Lanzhou University, Lanzhou, China2Department of Social Medicine and Health Management, School of Public Health, Lanzhou University, Lanzhou, China3Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON,...

April 1, 2020
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