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Alcoholism treatment is potentially effective against COVID-19

Alcoholism treatment is potentially effective against COVID-19

A team of chemists from HSE University and the Zelinsky Institute of Organic Chemistry used molecular modelling to find out that two medications that have been known for a long time can be used to fight SARS-CoV-2. These are disulfiram, which is used to treat alcoholism, and neratinib, an experimental drug being used to treat breast cancer. The paper about the discovery has been available online since August 4, 2020, in the 4th issue of Mendeleev Communications journal.The structural elements of the virus that are less subject to mutation during its evolution should be chosen as a target...

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HSE_eng
3d ago
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Chemists build natural anti-cancer compound with lean new process

Chemists build natural anti-cancer compound with lean new process

JUPITER, FL--Scripps Research chemists Hans Renata, PhD, and Alexander Adibekian, PhD, have discovered a way to efficiently create a synthetic version of a valuable natural compound called cepafungin I, which has shown promise as an anti-cancer agent.Through this, they were able to understand how the bacterial secretion is able to block a piece of molecular machinery known as a proteasome--a strategy that many existing cancer medications use to destroy tumor cells. They found that cepafungin I bound to not one but two places on the proteasome, enacting a powerful result. Their report...

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scrippsresearch
2d ago
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Blood-thinner with no bleeding side-effects is here

Blood-thinner with no bleeding side-effects is here

Patients who suffer from thrombosis, pulmonary embolism or stroke are usually put on drugs that help their blood flow more smoothly through their body. Occupying a large section of the drug market, anticoagulants, or "blood thinners" as they are popularly known, can keep blood clots from forming or getting bigger, and can therefore help with recover from heart defects or prevent further complications.But there is a catch: blood thinners work by blocking enzymes that help to stop bleeding after an injury. Because of this, virtually every blood thinner available today can lead to serious, and...

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EPFL_en
4d ago
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Scientists accelerate progress in preventing drug resistance in lung and pancreas cancers

Scientists accelerate progress in preventing drug resistance in lung and pancreas cancers

Scientists at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) report today the development of new models to study molecular characteristics of tumors of the lung and pancreasScientists at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) report today the development of new models to study molecular characteristics of tumors of the lung and pancreas that are driven by mutations in a gene named NTRK1. The findings were published today in the journal Cell Reports.In healthy bodies, NTRK1 has critical functions in the development of nerve cells, particularly...

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EurekAlert
4d ago
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Dome A in Antarctica is the best site for optical astronomical observation on Earth

Dome A in Antarctica is the best site for optical astronomical observation on Earth

A research team led by Prof. SHANG Zhaohui from National Astronomical Observatories of the Chinese Academy of Sciences (NAOC) has proved that Dome A in Antarctica is the best site for optical astronomical observation on Earth. The study was published in Nature on July 29.Seeing reflects the atmospheric turbulence that makes stars twinkle or smears star images observed by telescopes. At an observatory with good seeing, weak turbulence results in a smaller seeing value and sharper images. This is especially good for viewing faint objects. A small-aperture telescope at such a site can compete...

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EurekAlert
5d ago
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New studies show how to save parasites and why it's important

New studies show how to save parasites and why it's important

Parasites have a public relations problem.Unlike the many charismatic mammals, fishes and birds that receive our attention (and our conservation dollars), parasites are thought of as something to eradicate -- and certainly not something to protect.But only 4% of known parasites can infect humans, and the majority actually serve critical ecological roles, like regulating wildlife that might otherwise balloon in population size and become pests. Still, only about 10% of parasites have been identified and, as a result, they are mostly left out of conservation activities and research.An...

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UW
7d ago
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Nano-sponges of solid acid transform carbon dioxide to fuel and plastic waste to chemicals

Nano-sponges of solid acid transform carbon dioxide to fuel and plastic waste to chemicals

Solid acids are amongst the most essential heterogeneous catalysts, which have the potential to replace environmentally harmful liquid acids, in some of the most important processes, such as hydrocarbon cracking, alkylation, as well as plastic waste degradation and carbon dioxide to fuel conversion.Two best known solid acids are crystalline zeolites and amorphous aluminosilicates. Although zeolites are strongly acidic, they are limited by their inherent microporosity, causing extreme diffusion limitation, whereas aluminosilicates are although mesoporous, they suffer from low acidity and...

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EurekAlert
Jul 31
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'Drawn-on-skin' electronics offer breakthrough in wearable monitors

'Drawn-on-skin' electronics offer breakthrough in wearable monitors

A team of researchers led by Cunjiang Yu, Bill D. Cook Associate Professor of Mechanical Engineering at the University of Houston, has developed a new form of electronics known as "drawn-on-skin electronics," allowing multifunctional sensors and circuits to be drawn on the skin with an ink pen.The advance, the researchers report in , allows for the collection of more precise, motion artifact-free health data, solving the long-standing problem of collecting precise biological data through a wearable device when the subject is in motion.The imprecision may not be important when your FitBit...

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UH_News
Jul 30
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Engineering a carbon-negative power plant

Engineering a carbon-negative power plant

As renewable power generation increases, conventional energy sources like natural gas, coal, and nuclear power will still be required to balance the nation's energy portfolio. Traditional power plants will not, however, need to produce as much energy as they do now, leaving them to sit idle some of the time.Katherine Hornbostel, assistant professor of mechanical engineering and materials science at the University of Pittsburgh's Swanson School of Engineering, and her team received $800,283 in funding from the U.S. Department of Energy's Advanced Research Projects Agency-Energy (ARPA-E)...

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EurekAlert
Jul 29
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Electrons obey social distancing in 'strange' metals

Electrons obey social distancing in 'strange' metals

ITHACA, N.Y. - Quantum mechanics can seem a bit confounding, so for a quantum material to be called "strange" is really saying something.A Cornell University-led collaboration has used state-of-the-art computational tools to model the chaotic behavior of Planckian, or "strange," metals. This behavior has long intrigued physicists, but they have not been able to simulate it down to the lowest possible temperature until now.The team's paper, "Linear Resistivity and Sachdev-Ye-Kitaev (SYK) Spin Liquid Behaviour in a Quantum Critical Metal with Spin-1/2 Fermions," published July 22 in the...

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cornell
Jul 23
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Coral reefs show resilience to rising temperatures

Coral reefs show resilience to rising temperatures

Rising ocean temperatures have devastated coral reefs all over the world, but a recent study in Global Change Biology has found that reefs in the Eastern Tropical Pacific region may prove to be an exception. The findings, which suggest that reefs in this area may have adapted to heat stress, could provide insights about the potential for survival of reefs in other parts of the world. The study was published in print in July."Our 44-year study shows that the amount of living coral has not changed in the ETP," said James W. Porter, the paper's senior author. "Live coral cover has gone up and...

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universityofga
Jul 23
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Teen museum educators increase engagement, learning, in tween visitors

Teen museum educators increase engagement, learning, in tween visitors

Do you want to get the most out of a museum and encourage your child's interest in STEM? Try interacting with a teenaged museum docent. Research led by investigators from North Carolina State University and the University of Exeter in the U.K. has found that youth docents have an overall positive effect on visitors' experiences, learning and information retention at informal learning sites. The positive effects accrued across age groups regardless of museum type, but were most apparent in children ages 9 to 11.Informal learning sites - such as museums, zoos and aquariums - often have...

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NCStateNews
Jul 23
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New 'super light source' should allow fascinating insights into atoms

New 'super light source' should allow fascinating insights into atoms

The 'Gamma Factory initiative' - an international team of scientists - is currently exploring a novel research tool: They propose to develop a source of high-intensity gamma rays using the existing accelerator facilities at CERN. To do this, specialized ion beams will be circulated in the SPS and LHC storage rings, which will then be excited using laser beams so that they emit photons. In the selected configuration, the energies of the photons will be within the gamma radiation range of the electromagnetic spectrum. This is of particular interest in connection with spectroscopic analysis of...

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uni_mainz_eng
Jul 22
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International analysis narrows range of climate's sensitivity to CO2

International analysis narrows range of climate's sensitivity to CO2

The most advanced and comprehensive analysis of climate sensitivity yet undertaken has revealed with more confidence than ever before how sensitive the Earth's climate is to carbon dioxide.For more than 40 years, the estimated likely range of the eventual global temperature response to a doubling of atmospheric carbon dioxide compared to preindustrial levels has stubbornly remained at 1.5°C - 4.5°C.This new research, revealed in a 165 page, peer-reviewed journal article commissioned by the World Climate Research Programme (WCRP) written over four years, finds that the true climate...

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UNSWnews
Jul 22
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Another mRNA-based vaccine candidate protects animals against SARS-CoV-2

Another mRNA-based vaccine candidate protects animals against SARS-CoV-2

An experimental messenger RNA (mRNA)-based vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) elicits protective immune responses in mice and non-human primates, researchers report on July 23rd in the journal Cell. Two injections of the vaccine were sufficient to induce robust immunity, completely preventing SARS-CoV-2 infection in mice."The robust protection observed in the present studies and the clear immune correlates of protection pave the path forward for future COVID-19 vaccine development in humans," says senior study author Cheng-Feng Qin of the Beijing...

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CellPressNews
Jul 24
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Researchers discover hybrid fungus involved in lung infections

Researchers discover hybrid fungus involved in lung infections

Aspergillus latus, a species of fungus previously found only in soil or plants, has been found for the first time in a hospital environment by an international group of researchers. The group sequenced its genome and discovered that it is actually a hybrid and is up to three times more drug-resistant than the two species from which it derives.An article on the study is in Current Biology and coauthored by researchers from Brazil, the United States, Portugal and Belgium. The research was supported by São Paulo Research Foundation - .Aspergillosis is a lung disease caused by fungi of this...

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AgenciaFAPESP
Jul 17
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Antarctica more widely impacted by humans than previously thought

Antarctica more widely impacted by humans than previously thought

Antarctica is considered one of the Earth's largest, most pristine remaining wildernesses. Yet since its formal discovery 200 years ago, the continent has seen accelerating and potentially impactful human activity.How widespread this activity is across the continent has never been quantified. We know Antarctica has no cities, agriculture or industry. But we have never had a good idea of where humans have been, how much of the continent remains untouched or largely unimpacted, and to what extent these largely unimpacted areas serve to protect biodiversity.A team of researchers led by Monash...

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Wits_News
Jul 17
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Ultracold mystery: Solved

Ultracold mystery: Solved

In a famous parable, three blind men encounter an elephant for the first time. Each touches a part--the trunk, ear, or side--and concludes the creature is a thick snake, fan, or wall. This elephant, said Kang-Kuen Ni, is like the quantum world. Scientists can only explore a cell of this vast, unknown creature at a time. Now, Ni has revealed a few more to explore.It all started last December, when she and her team completed a new apparatus that could achieve the lowest temperature chemical reactions of any currently available technology and then broke and formed the coldest bonds in the...

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HarvardResearch
Jul 20
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Keeping innocent people out of jail using the science of perception

Keeping innocent people out of jail using the science of perception

LA JOLLA--(July 14, 2020) People wrongfully accused of a crime often wait years--if ever--to be exonerated. Many of these wrongfully accused cases stem from unreliable eyewitness testimony. Now, Salk scientists have identified a new way of presenting a lineup to an eyewitness that could improve the likelihood that the correct suspect is identified and reduce the number of innocent people sentenced to jail. Their report is published in Nature Communications on July 14, 2020."Misidentification by eyewitnesses is a long-standing problem in our society. Our new lineup method uncovers the...

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salkinstitute
Jul 14
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COVID-19 lockdown reduced dangerous air pollutants in five Indian cities by up to 54 percent

COVID-19 lockdown reduced dangerous air pollutants in five Indian cities by up to 54 percent

A team of 10 interdisciplinary researchers from the University of Surrey's renowned Global Centre for Clean Air Research (GCARE), including PhD students and post-doctoral researchers, have united to develop a rapid assessment of the impact COVID-19 has had on air quality.Figures from the World Health Organisation show the ongoing pandemic has caused more than 477,000 deaths worldwide as of June 2020, 14,000 of which occurred in India. On 25 March 2020, a complete lockdown of internal and external boarders together with social isolation measures came into effect in India, affecting the lives...

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UniOfSurrey
Jul 16
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Image

Image

The vast universe can always arise people's infinite imagination and yearning. Black hole, as one of the most attractive heavenly bodies in the universe, are waiting to be explored and studied. However, due to the limitations of technology, human is still unable to go into the depths of universe, let alone reach the vicinity of a black hole.Fortunately, based on the equivalence between the metric of curved space-time in general relativity and the electromagnetic parameters in electromagnetic materials, the physical scientist has developed the method of transformation optics to simulate the...

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EurekAlert
Jul 16
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Common FDA-approved drug may effectively neutralize virus that causes COVID-19

Common FDA-approved drug may effectively neutralize virus that causes COVID-19

TROY, N.Y. -- A common drug, already approved by the Food and Drug Administration (FDA), may also be a powerful tool in fighting COVID-19, according to research published this week in Antiviral Research.SARS-CoV-2, the virus that causes COVID-19, uses a surface spike protein to latch onto human cells and initiate infection. But heparin, a blood thinner also available in non-anticoagulant varieties, binds tightly with the surface spike protein, potentially blocking the infection from happening. This makes it a decoy, which might be introduced into the body using a nasal spray or nebulizer...

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rpinews
Jul 15
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About 94 per cent of wild bee and native plant species networks lost, York study finds

About 94 per cent of wild bee and native plant species networks lost, York study finds

TORONTO, July 14, 2020 - Climate change and an increase in disturbed bee habitats from expanding agriculture and development in northeastern North America over the last 30 years are likely responsible for a 94 per cent loss of plant-pollinator networks, York University researchers found.The researchers, corresponding author Professor Sandra Rehan of the Faculty of Science and grad student Minna Mathiasson of the University of New Hampshire, looked at plant-pollinator networks from 125 years ago through present day. The networks are comprised of wild bees and the native plants they...

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YorkUnews
Jul 14
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Russian scientists have discovered a new physical paradox

Russian scientists have discovered a new physical paradox

Researchers from the (SPbPU) discovered and theoretically explained a new physical effect: amplitude of mechanical vibrations can grow without external influence. Besides, the scientific group offered their explanation on how to eliminate the Fermi-Pasta-Ulam-Tsingou paradox.The scientists of SPbPU explained it using a simple example: to rock the swing, you have to keep pushing it. It is generally believed that it is impossible to achieve oscillatory resonance without constant external influence.However, the scientific group of the Higher School of Theoretical Mechanics, Institute of...

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pgpuspb
Jul 13
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Elderly people's response to COVID-19 not as expected

Elderly people's response to COVID-19 not as expected

Survey results from 27 countries suggest that, despite their increased risk of severe illness due to COVID-19, elderly people are not more willing to isolate when asked to, and are not more compliant with several COVID-19 preventive measures. Jean-François Daoust of the University of Edinburgh, U.K., presents these findings in the open-access journal PLOS ONE on July 2, 2020.Among those who become ill with COVID-19, older adults appear to be more likely to be hospitalized or die from the disease. Because of their increased vulnerability, one might expect that elderly people would be more...

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EurekAlert
Jul 2
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