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Thousands of human sequences provide deep insight into single genomes

Thousands of human sequences provide deep insight into single genomes

What do the differences between each person’s genetic code mean for their individual development and health? Several factors have hampered researchers’ ability to answer this question. First, understanding genetic variation requires analysing huge numbers of sequences, because we carry many rare variants. Most of these have no effect, with just a few causing genetic diseases. Second, most of our understanding of genetic variation has come from studying single nucleotide variants (SNVs), but structural variants — more than 50 nucleotides long — can have a larger impact on physiological...

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5d ago
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The epic battle against coronavirus misinformation and conspiracy theories

The epic battle against coronavirus misinformation and conspiracy theories

In the first few months of 2020, wild conspiracy theories about Bill Gates and the new coronavirus began sprouting online. Gates, the Microsoft co-founder and billionaire philanthropist who has funded efforts to control the virus with treatments, vaccines and technology, had himself created the virus, argued one theory. He had patented it, said another. He’d use vaccines to control people, declared a third. The false claims quietly proliferated among groups predisposed to spread the message — people opposed to vaccines, globalization or the privacy infringements enabled by technology. Then...

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5d ago
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Quantum clocks and the temporal localisability of events in the presence of gravitating quantum systems

Quantum clocks and the temporal localisability of events in the presence of gravitating quantum systems

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.A Nature Research JournalWe’d like to understand how you use our websites in order to improve them.The standard formulation of quantum theory relies on a fixed space-time metric determining the localisation and causal order of events. In general relativity, the...

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3d ago
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Aluminium in human brain tissue from donors without neurodegenerative disease: A comparison with Alzheimer’s disease, multiple sclerosis and autism

Aluminium in human brain tissue from donors without neurodegenerative disease: A comparison with Alzheimer’s disease, multiple sclerosis and autism

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.A Nature Research JournalWe’d like to understand how you use our websites in order to improve them.A burgeoning number of studies are demonstrating aluminium in human brain tissue. While research has both quantified and imaged aluminium in human brain tissue in...

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May 8
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A high biodiversity mitigates the impact of ocean acidification on hard-bottom ecosystems

A high biodiversity mitigates the impact of ocean acidification on hard-bottom ecosystems

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.A Nature Research JournalWe’d like to understand how you use our websites in order to improve them.Biodiversity loss and climate change simultaneously threaten marine ecosystems, yet their interactions remain largely unknown. Ocean acidification severely affects a...

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Feb 19
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Continuous crystalline graphene papers with gigapascal strength by intercalation modulated plasticization

Continuous crystalline graphene papers with gigapascal strength by intercalation modulated plasticization

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.A Nature Research JournalWe’d like to understand how you use our websites in order to improve them.Graphene has an extremely high in-plane strength yet considerable out-of-plane softness. High crystalline order of graphene assemblies is desired to utilize their...

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5d ago
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The mutational constraint spectrum quantified from variation in 141,456 humans

The mutational constraint spectrum quantified from variation in 141,456 humans

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.A Nature Research JournalWe’d like to understand how you use our websites in order to improve them.Genetic variants that inactivate protein-coding genes are a powerful source of information about the phenotypic consequences of gene disruption: genes that are crucial...

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5d ago
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A census of baryons in the Universe from localized fast radio bursts

A census of baryons in the Universe from localized fast radio bursts

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.A Nature Research JournalWe’d like to understand how you use our websites in order to improve them.More than three-quarters of the baryonic content of the Universe resides in a highly diffuse state that is difficult to detect, with only a small fraction directly...

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5d ago
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Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin

Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.We’d like to understand how you use our websites in order to improve them.There is growing interest in the therapeutic utility of psychedelic substances, like psilocybin, for disorders characterized by distortions of the self-experience, like depression. Accumulating...

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May 23
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Triterpenoid acids isolated from Schinus terebinthifolia fruits reduce Staphylococcus aureus virulence and abate dermonecrosis

Triterpenoid acids isolated from Schinus terebinthifolia fruits reduce Staphylococcus aureus virulence and abate dermonecrosis

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.A Nature Research JournalWe’d like to understand how you use our websites in order to improve them.Staphylococcus aureus relies on quorum sensing to exert virulence to establish and maintain infection. Prior research demonstrated the potent quorum sensing inhibition...

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May 15
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GPSeq reveals the radial organization of chromatin in the cell nucleus

GPSeq reveals the radial organization of chromatin in the cell nucleus

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.A Nature Research JournalWe’d like to understand how you use our websites in order to improve them.With the exception of lamina-associated domains, the radial organization of chromatin in mammalian cells remains largely unexplored. Here we describe genomic loci...

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7d ago
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The intensification of Arctic warming as a result of CO2 physiological forcing

The intensification of Arctic warming as a result of CO2 physiological forcing

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.A Nature Research JournalWe’d like to understand how you use our websites in order to improve them.Stomatal closure is one of the main physiological responses to increasing CO2 concentration, which leads to a reduction in plant water loss. This response has the...

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Apr 29
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Tracking the Near Eastern origins and European dispersal of the western house mouse

Tracking the Near Eastern origins and European dispersal of the western house mouse

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.A Nature Research JournalWe’d like to understand how you use our websites in order to improve them.The house mouse (Mus musculus) represents the extreme of globalization of invasive mammals. However, the timing and basis of its origin and early phases of dispersal...

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May 19
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Gene–obesogenic environment interactions on body mass indices for older black and white men and women from the Health and Retirement Study

Gene–obesogenic environment interactions on body mass indices for older black and white men and women from the Health and Retirement Study

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.We’d like to understand how you use our websites in order to improve them.Gene–obesogenic environment interactions influence body mass index (BMI) across the life course; however, limited research examines how these interactions may differ by race and sex.Utilizing...

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May 18
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Ultra-dense optical data transmission over standard fibre with a single chip source

Ultra-dense optical data transmission over standard fibre with a single chip source

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.A Nature Research JournalWe’d like to understand how you use our websites in order to improve them.Micro-combs - optical frequency combs generated by integrated micro-cavity resonators – offer the full potential of their bulk counterparts, but in an integrated...

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May 22
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Gravitational-wave asteroseismology with fundamental modes from compact binary inspirals

Gravitational-wave asteroseismology with fundamental modes from compact binary inspirals

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.A Nature Research JournalWe’d like to understand how you use our websites in order to improve them.Gravitational waves (GWs) from binary neutron stars encode unique information about ultra-dense matter through characterisic signatures associated with a variety of...

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May 21
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Viral and host factors related to the clinical outcome of COVID-19

Viral and host factors related to the clinical outcome of COVID-19

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.A Nature Research JournalWe’d like to understand how you use our websites in order to improve them.In December 2019, the Coronavirus disease 2019 (COVID-19), caused by a novel coronavirus SARS-CoV-2, emerged in Wuhan, Hubei province, China1 and soon spread across the...

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May 20
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How coronavirus lockdowns stopped flu in its tracks

How coronavirus lockdowns stopped flu in its tracks

Lockdowns and social-distancing measures aimed at slowing the spread of coronavirus seem to have shortened the influenza season in the northern hemisphere by about six weeks. Globally, an estimated 290,000–650,000 people typically die from seasonal flu, so a shorter flu season could mean tens of thousands of lives are spared. But the net impacts on global health will be hard to unpick against the large number of deaths from COVID-19 as well as other causes in 2020 and beyond. Tracking influenza and other infectious diseases can help to reveal the effectiveness of public-health policies...

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May 21
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The first footprints on Mars could belong to this geologist

The first footprints on Mars could belong to this geologist

Jessica Watkins spent her PhD studying landslides on Mars. Now she is among the few humans with a shot at being the first to walk on the red planet.In January, Watkins graduated as a member of NASA’s newest astronaut class. As a planetary geologist, she is a leading candidate to participate in the agency’s Artemis programme, which aims to send people back to the Moon by the end of 2024. Further down the line — Watkins is only 32 years old — there might even be a trip to Mars.More immediately, Watkins is helping two of her fellow astronauts to prepare for a milestone launch on 27 May, which...

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May 19
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Interference of chiral Andreev edge states

Interference of chiral Andreev edge states

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.A Nature Research JournalWe’d like to understand how you use our websites in order to improve them.The search for topological excitations such as Majorana fermions has spurred interest in the boundaries between distinct quantum states. Here, we explore an interface...

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May 18
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Remote sensing reveals Antarctic green snow algae as important terrestrial carbon sink

Remote sensing reveals Antarctic green snow algae as important terrestrial carbon sink

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.A Nature Research JournalWe’d like to understand how you use our websites in order to improve them.We present the first estimate of green snow algae community biomass and distribution along the Antarctic Peninsula. Sentinel 2 imagery supported by two field campaigns...

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May 20
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Temporary reduction in daily global CO2 emissions during the COVID-19 forced confinement

Temporary reduction in daily global CO2 emissions during the COVID-19 forced confinement

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.A Nature Research JournalWe’d like to understand how you use our websites in order to improve them.Government policies during the COVID-19 pandemic have drastically altered patterns of energy demand around the world. Many international borders were closed and...

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May 19
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Synthesis of mesoscale ordered two-dimensional π-conjugated polymers with semiconducting properties

Synthesis of mesoscale ordered two-dimensional π-conjugated polymers with semiconducting properties

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.A Nature Research JournalWe’d like to understand how you use our websites in order to improve them.Two-dimensional materials with high charge carrier mobility and tunable band gaps have attracted intense research effort for their potential use in nanoelectronics....

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May 18
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An interpretable mortality prediction model for COVID-19 patients

An interpretable mortality prediction model for COVID-19 patients

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.A Nature Research JournalWe’d like to understand how you use our websites in order to improve them.The sudden increase in COVID-19 cases is putting high pressure on healthcare services worldwide. At this stage, fast, accurate and early clinical assessment of the...

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May 14
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Accurate deep neural network inference using computational phase-change memory

Accurate deep neural network inference using computational phase-change memory

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May 18
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