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Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementThe rapid development of the CRISPR–Cas9, –Cas12a and –Cas12b genome editing systems has greatly fuelled basic and translational plant research,,,,,. DNA targeting by these Cas nucleases is restricted by their preferred protospacer adjacent motifs...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementThe rapid development of the CRISPR–Cas9, –Cas12a and –Cas12b genome editing systems has greatly fuelled basic and translational plant research,,,,,. DNA targeting by these Cas nucleases is restricted by their preferred protospacer adjacent motifs...WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementThe Sun provides the principal energy input into the Earth system and solar variability represents a significant external climate forcing. Although observations of solar activity (sunspots) cover only the last about 400 years, radionuclides produced by...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementThe Sun provides the principal energy input into the Earth system and solar variability represents a significant external climate forcing. Although observations of solar activity (sunspots) cover only the last about 400 years, radionuclides produced by...WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementSodium ion batteries, because of their sustainability attributes, could be an attractive alternative to Li-ion technology for specific applications. However, it remains challenging to design high energy density and moisture stable Na-based positive...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementSodium ion batteries, because of their sustainability attributes, could be an attractive alternative to Li-ion technology for specific applications. However, it remains challenging to design high energy density and moisture stable Na-based positive...WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementThe idea that dietary restriction can be used as a tool to increase lifespan has been a centrepiece of ageing research for decades. But the mechanisms by which dietary restriction might act, and the specific nutritional components involved, remain...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementThe idea that dietary restriction can be used as a tool to increase lifespan has been a centrepiece of ageing research for decades. But the mechanisms by which dietary restriction might act, and the specific nutritional components involved, remain...WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementThe effects of tobacco control policies on global smoking prevalenceSubstantial global effort has been devoted to curtailing the tobacco epidemic over the past two decades, especially after the adoption of the Framework Convention on Tobacco Control by...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementThe effects of tobacco control policies on global smoking prevalenceSubstantial global effort has been devoted to curtailing the tobacco epidemic over the past two decades, especially after the adoption of the Framework Convention on Tobacco Control by...WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementDiscarded plastic is a marine menace, entangling whales and filling seabirds’ stomachs. But deep-ocean plastic dumps can be havens of biodiversity.Xikun Song at Xiamen University in China, Xiaotong Peng at the Chinese Academy of Sciences in Sanya and...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementDiscarded plastic is a marine menace, entangling whales and filling seabirds’ stomachs. But deep-ocean plastic dumps can be havens of biodiversity.Xikun Song at Xiamen University in China, Xiaotong Peng at the Chinese Academy of Sciences in Sanya and...WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementSpin excitations of magnetic thin films are the founding element for magnetic devices in general. While spin dynamics have been extensively studied in bulk materials, the behaviour in mesoscopic films is less known due to experimental limitations. Here,...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementSpin excitations of magnetic thin films are the founding element for magnetic devices in general. While spin dynamics have been extensively studied in bulk materials, the behaviour in mesoscopic films is less known due to experimental limitations. Here,...WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementMOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasisHealthy aging can be promoted by enhanced metabolic fitness and physical capacity. Mitochondria are chief metabolic organelles with...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementMOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasisHealthy aging can be promoted by enhanced metabolic fitness and physical capacity. Mitochondria are chief metabolic organelles with...WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementEvolution of antibody immunity to SARS-CoV-2Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected 78 million individuals and is responsible for over 1.7 million deaths to date. Infection is associated with development of variable...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementEvolution of antibody immunity to SARS-CoV-2Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has infected 78 million individuals and is responsible for over 1.7 million deaths to date. Infection is associated with development of variable...WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementIn the middle of the pandemic, I got an e-mail asking whether I had access to data from the experiments behind a paper I’d published in 2014. Three months later, I requested that the paper be retracted. The experience has not left me bitter: if anything,...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementIn the middle of the pandemic, I got an e-mail asking whether I had access to data from the experiments behind a paper I’d published in 2014. Three months later, I requested that the paper be retracted. The experience has not left me bitter: if anything,...WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementA new mouse model for retinal degeneration due to Fam161a deficiencyFAM161A mutations are the most common cause of inherited retinal degenerations in Israel. We generated a knockout (KO) mouse model, Fam161atm1b/tm1b, lacking the major exon #3 which was...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementA new mouse model for retinal degeneration due to Fam161a deficiencyFAM161A mutations are the most common cause of inherited retinal degenerations in Israel. We generated a knockout (KO) mouse model, Fam161atm1b/tm1b, lacking the major exon #3 which was...WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementMore than a year after COVID-19 emerged, many mysteries persist about the disease: why do some people get so much sicker than others? Why does lung damage sometimes continue to worsen well after the body seems to have cleared the SARS-CoV-2 virus? And...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementMore than a year after COVID-19 emerged, many mysteries persist about the disease: why do some people get so much sicker than others? Why does lung damage sometimes continue to worsen well after the body seems to have cleared the SARS-CoV-2 virus? And...WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementEffects of social distancing on the spreading of COVID-19 inferred from mobile phone dataA better understanding of how the COVID-19 pandemic responds to social distancing efforts is required for the control of future outbreaks and to calibrate partial...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementEffects of social distancing on the spreading of COVID-19 inferred from mobile phone dataA better understanding of how the COVID-19 pandemic responds to social distancing efforts is required for the control of future outbreaks and to calibrate partial...WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementLooking beyond COVID-19 vaccine phase 3 trialsAfter the recent announcement of COVID-19 vaccine efficacy in clinical trials by several manufacturers for protection against severe disease, a comprehensive post-efficacy strategy for the next steps to...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementLooking beyond COVID-19 vaccine phase 3 trialsAfter the recent announcement of COVID-19 vaccine efficacy in clinical trials by several manufacturers for protection against severe disease, a comprehensive post-efficacy strategy for the next steps to...WW…

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Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementUtilizing the National Basketball Association’s COVID-19 restart “bubble” to uncover the impact of travel and circadian disruption on athletic performanceOn March 11th, 2020, the National Basketball Association (NBA) paused its season after ~ 64 games...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementUtilizing the National Basketball Association’s COVID-19 restart “bubble” to uncover the impact of travel and circadian disruption on athletic performanceOn March 11th, 2020, the National Basketball Association (NBA) paused its season after ~ 64 games...WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementThe dominant feature of large-scale mass transfer in the modern ocean is the Atlantic meridional overturning circulation (AMOC). The geometry and vigour of this circulation influences global climate on various timescales. Palaeoceanographic evidence...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementThe dominant feature of large-scale mass transfer in the modern ocean is the Atlantic meridional overturning circulation (AMOC). The geometry and vigour of this circulation influences global climate on various timescales. Palaeoceanographic evidence...WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementDNA has been the predominant information storage medium for biology and holds great promise as a next-generation high-density data medium in the digital era. Currently, the vast majority of DNA-based data storage approaches rely on in vitro DNA...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementDNA has been the predominant information storage medium for biology and holds great promise as a next-generation high-density data medium in the digital era. Currently, the vast majority of DNA-based data storage approaches rely on in vitro DNA...WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementFacial recognition technology can expose political orientation from naturalistic facial imagesUbiquitous facial recognition technology can expose individuals’ political orientation, as faces of liberals and conservatives consistently differ. A facial...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementFacial recognition technology can expose political orientation from naturalistic facial imagesUbiquitous facial recognition technology can expose individuals’ political orientation, as faces of liberals and conservatives consistently differ. A facial...WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementVisual behavior modelling for robotic theory of mindBehavior modeling is an essential cognitive ability that underlies many aspects of human and animal social behavior (Watson in Psychol Rev 20:158, 1913), and an ability we would like to endow robots....…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementVisual behavior modelling for robotic theory of mindBehavior modeling is an essential cognitive ability that underlies many aspects of human and animal social behavior (Watson in Psychol Rev 20:158, 1913), and an ability we would like to endow robots....WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementA fortnight before the adoption of the 2015 Paris climate agreement, India’s government published a report that could have imperilled the talks.Developing countries were being asked to commit to reducing their greenhouse-gas emissions. In exchange, they...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementA fortnight before the adoption of the 2015 Paris climate agreement, India’s government published a report that could have imperilled the talks.Developing countries were being asked to commit to reducing their greenhouse-gas emissions. In exchange, they...WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementThe fatty-acid amide hydrolase inhibitor URB597 inhibits MICA/B sheddingMICA/B proteins are expressed on the surface of various types of stressed cells, including cancer cells. Cytotoxic lymphocytes expressing natural killer group 2D (NKG2D) receptor...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementThe fatty-acid amide hydrolase inhibitor URB597 inhibits MICA/B sheddingMICA/B proteins are expressed on the surface of various types of stressed cells, including cancer cells. Cytotoxic lymphocytes expressing natural killer group 2D (NKG2D) receptor...WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementMetabolic changes and anti-tumor effects of a ketogenic diet combined with anti-angiogenic therapy in a glioblastoma mouse modelThe ketogenic diet (KD) is a high fat and low carbohydrate diet that produces ketone bodies through imitation of starvation....…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementMetabolic changes and anti-tumor effects of a ketogenic diet combined with anti-angiogenic therapy in a glioblastoma mouse modelThe ketogenic diet (KD) is a high fat and low carbohydrate diet that produces ketone bodies through imitation of starvation....WW…

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementA powerful method that combines microscopy and genomic analysis can reveal the organization and sequence of DNA inside intact cells. Fei Chen at the Broad Institute of MIT and Harvard in Cambridge, Massachusetts, and his colleagues fixed cells to...…Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtainthe best experience, we recommend you use a more up to date browser (or turn off compatibility mode inInternet Explorer). In the meantime, to ensure continued support, we are displaying the site without stylesand JavaScript.AdvertisementA powerful method that combines microscopy and genomic analysis can reveal the organization and sequence of DNA inside intact cells. Fei Chen at the Broad Institute of MIT and Harvard in Cambridge, Massachusetts, and his colleagues fixed cells to...WW…