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NAD+ Binds to and Inhibits a Protein that Promotes Degeneration of Neurons

NAD+ Binds to and Inhibits a Protein that Promotes Degeneration of Neurons

STUDIESSUBSCRIBENeurologicalInvestigators propose that a newly revealed nicotinamide adenine dinucleotide (NAD+) binding site of Sarm1 may be a promising drug target.Degeneration of axons, which transmit signals from one neuron to another, occurs in neurological diseases. A molecule called nicotinamide adenine dinucleotide (NAD+) has a crucial role in the maintenance of axons through unclear actions on a protein called Sarm1 that when activated can cause degeneration of neurons, the progressive atrophy and loss of function of neurons.Recently, scientists from Peking University in Beijing,...

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3d ago
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A Nutrition Guide for Memory Loss Care and Prevention

A Nutrition Guide for Memory Loss Care and Prevention

STUDIESSUBSCRIBEWhen equipped with the right dietary guidelines, vitamins, and social support from close relatives, senior adults can help mitigate and prevent loss of memory. This comprehensive guide shares some of the most simple tactics when it comes to battling disorders that target a person's memory.Memoryproblems are a major issue facing senior adults in the United States. In fact,as many as 40% of U.S. adults over the age of 65 as they age. On top of being inconvenient or frustrating, memory losscan have a variety of health consequences, ranging from minor issues topotentially...

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4d ago
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Cellular NAD+ Levels Modulate the Immune Response to COVID-19

Cellular NAD+ Levels Modulate the Immune Response to COVID-19

STUDIESSUBSCRIBEImmunityResearchers propose that increasing NAD+ levels improves immune function in COVID-19 infection.NAD+ is involved in multiple cellular reactions for the generation of energy and maintenance of cellular health, including immune responses to viral infections. Studies indicate cellular in people, and lower NAD+ levels associated with older age can adversely affect the immune response to infection, which includes the response to COVID-19. The death rates from COVID-19 increase with age, and for people above 80 years old, it passes 14%, which suggests an age-related...

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6d ago
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The Subdivision of NAD+ into Cell Compartments is Critical to Mammalian Life

The Subdivision of NAD+ into Cell Compartments is Critical to Mammalian Life

STUDIESSUBSCRIBELongevityResearchers review evidence supporting the importance of how nicotinamide adenine dinucleotide (NAD+) is distributed to different cell structures in health, disease, and aging.Nicotinamide adenine dinucleotide (NAD+) is a vital molecule with many biological functions. The roles of NAD+ are organized and coordinated by how it is subdivided into different structures within cells. The distribution of this critical compound within the cell is key to understanding the impact of NAD+ on biological processes, diseases, and .Investigators from the University of Texas at...

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7d ago
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Binge Drinking Causes Liver Damage by Reducing Cellular Levels of NAD+

Binge Drinking Causes Liver Damage by Reducing Cellular Levels of NAD+

STUDIESSUBSCRIBEMetabolismExcessive alcohol consumption and binge drinking reduce levels of free nicotinamide adenine dinucleotide (NAD+) critical to cellular health and energy production, resulting in liver and organ damage.Alcohol consumption can provide a welcome reprieve from the hassles of every-day life but can lead to binge drinking and excessive alcohol consumption. Over time, excessive alcohol use results in the development of chronic diseases and other serious problems.UCLA scientist and pathologist Dr. Samuel French published a review on the . In his review, Dr. French...

nmn.com
Oct 21
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Enzyme Regulating NAD+ Keeps Mouse Cells Replicating Under Stress

Enzyme Regulating NAD+ Keeps Mouse Cells Replicating Under Stress

STUDIESSUBSCRIBELongevityGenetically modified mouse cells with artificial activation of a nicotinamide adenine dinucleotide (NAD+) regulating enzyme are protected from cessation of cell proliferation induced by stress.Senescence, when cells can no longer divide and replicate, is central to aging. Accumulation of these senescent cells can be induced by excessive stress or replication of cells and reduces the ability of tissues to function and regenerate in aged organisms. Involved in this process is an enzyme called nicotinamide phosphoribosyltransferase (Nampt) that is critical for the...

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Oct 20
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Two Molecules Targeting Mitochondria Synergistically Improve Aged Heart Function

Two Molecules Targeting Mitochondria Synergistically Improve Aged Heart Function

STUDIESSUBSCRIBECardiovascularScientists that treated old mice with the molecules SS-31 and NMN separately improved different heart functions and when delivered together acted synergistically to recapitulate the function and metabolism of young hearts.Cardiovascular disease is a major cause of death in older people, with greater mortality than all types of cancer in adults older than 75 years of age combined. When heart function declines with age, phases of the heartbeat get disrupted–specifically, when the heart fills with and pumps out blood. Due to the mortality rate from cardiovascular...

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Oct 20
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NR Does Not Improve Mitochondrial Function or NAD+ Content in Human Skeletal Muscle After Long-Term Administration

NR Does Not Improve Mitochondrial Function or NAD+ Content in Human Skeletal Muscle After Long-Term Administration

STUDIESSUBSCRIBENRA long-term clinical study from Denmark showed that increased nicotinamide adenine dinucleotide (NAD+) content and improved mitochondrial function induced by nicotinamide riboside (NR) supplementation in mouse skeletal muscle does not translate into humans.Increasing nicotinamide adenine dinucleotide (NAD+) levels with precursors like nicotinamide riboside (NR) has gained popularity as a strategy to combat against age-related diseases associated with dysfunction of the cell’s powerhouse, the mitochondria. Clinical trials evaluating the effects of supplementing with NR to...

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Oct 17
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NR Can Enhance T Cell Antitumor Immunity by Restoring Mitochondrial Function

NR Can Enhance T Cell Antitumor Immunity by Restoring Mitochondrial Function

STUDIESSUBSCRIBECancerT lymphocytes that infiltrate and suppress tumors progressively lose their ability to function, but nicotinamide riboside (NR) supplementation enhances T cell mitochondrial fitness to sustain the antitumor response.The body’s immune response to cancer comes, in part, from a type of white blood cell called T lymphocytes. Depletion of nutrients, a metabolic challenge, from the cellular environments that tumors create set up challenges for T lymphocyte antitumor responses, resulting in T cell dysfunction. Figuring out the mechanisms behind the effects tumors have on T...

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Oct 16
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NAD+ Keeps the Mouse Body Clock Young to Counter Aging

NAD+ Keeps the Mouse Body Clock Young to Counter Aging

STUDIESSUBSCRIBELongevityBoosting nicotinamide adenine dinucleotide (NAD+) levels restores improves circadian rhythms in old mice through youthful gene activation and metabolic patterns, revealing that NAD+ governs both behavior and metabolic health.Circadian rhythms—physical, mental, and behavioral changes that follow a daily cycle, such as the —get disrupted as we get older, which can contribute to the development of diseases associated with aging. However, the mechanisms and signals that link circadian rhythms and aging are unclear.A research team from Northwestern University published...

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Oct 16
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Boosting NAD+ levels improves heart function in mice with heart failure

Boosting NAD+ levels improves heart function in mice with heart failure

Thursday, September 3, 2020SUBSCRIBECardiovascularA study from Duke University indicated that NMN supplementation improves function in mice with heart disease via boosting NAD+ levels and SIRT3 activity.BWApproximately in the United States had heart failure in 2019, and heart failure contributed to 1 in 8 deaths in 2017. The condition cost the nation an estimated $30.7 billion in 2012. In 2017, scientists from Duke University found that a molecule called nicotinamide mononucleotide (NMN) had therapeutic efficacy in mice with heart failure.  Previous studies have shown supplementing with NMN...

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Sep 3
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Scientists at Nanchang University improve bone formation deficiencies in glucocorticoid-induced osteoporosis

Scientists at Nanchang University improve bone formation deficiencies in glucocorticoid-induced osteoporosis

Thursday, August 27, 2020SUBSCRIBEOthersScientists at Nanchang University discovered NMN may be a therapeutic option for glucocorticoid-induced osteoporosis.BWOf the major side effects from glucocorticoid-induced osteoporosis, bone fractures are among the most devastating, affecting diagnosed with osteoporosis. Clinicians use glucocorticoids, such as dexamethasone and hydrocortisone to treat patients with inflammation, immunological rejection of transplanted tissue, and autoimmune diseases. In glucocorticoid-induced osteoporosis, patients have “porous bone” when viewed under a microscope,...

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Aug 27
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Neuroprotective chemicals prevent neurodegeneration and preserve function after traumatic brain injury

Neuroprotective chemicals prevent neurodegeneration and preserve function after traumatic brain injury

Wednesday, August 26, 2020SUBSCRIBENeurologicalScientists hope that neuroprotective chemicals called P7C3 will become new interventions for nerve cell dysfunction that currently lack treatment optionsBy Tiffany ChenOn the afternoon of August 4, 2020, grey smoke with white flashes rumbled into the air at the port of Beirut. At 6:09 p.m., an explosion sent a powerful shockwave throughout the seaside city, shattering glasses, stripping away walls, exposing the rebars — skinning the buildings naked. The blast left hundreds dead and thousands injured. Many of those injured may develop traumatic...

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Aug 26
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Scientists improve muscle development in zebrafish with neuromuscular disease

Scientists improve muscle development in zebrafish with neuromuscular disease

Saturday, August 22, 2020SUBSCRIBESkin & MuscleWhen given before muscle development, NAD+ or B3 vitamins supplementation can improve muscular health in zebrafish.BWDystroglycanopathies represent forms of , which present as severe mental retardation and brain and eye malformations. The rare genetic disorder results in muscle development abnormalities and can be lethal. In 2019, scientists from the University of Maine published in Skeletal Muscle where they found supplementing with a molecule called nicotinamide adenine dinucleotide (NAD+) improved neuromuscular development in zebrafish with...

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Aug 22
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Aging might be reversible — fixing the miscommunications in cells

Aging might be reversible — fixing the miscommunications in cells

Saturday, August 22, 2020SUBSCRIBEMetabolismMiscommunication between mitochondria and the nucleus accelerates aging, but NAD+ supplementation helps restore the conversation and reverses signs of aging.ByOur cells are like intricate machinery that rely on different components’ cooperation and communication, especially between the central command center and the powerhouse — the nucleus and mitochondria. In 2013, Scientists at Harvard University discovered that the communication breakdown between the two organelles in mice leads to accelerated aging. On the bright side, it might be reversible...

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Aug 22
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Eating less reduces plaque buildup in Alzheimer’s disease

Eating less reduces plaque buildup in Alzheimer’s disease

Saturday, August 22, 2020SUBSCRIBENeurologicalScientists provide evidence elucidating the cellular pathway by which calorie restriction reduces plaque buildup in Alzheimer’s disease.BWAn estimated people aged 65 and older in the US live with Alzheimer’s disease in 2020, and an estimated 13.8 million people will have Alzheimer’s dementia by 2050. In the medical field, 50 percent of physicians believe the society is not ready for the growing prevalence of this disease. Scientists have been searching for therapeutic options for the memory-impairing diseases since it was first described in...

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Aug 22
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NAD+ supplementation could mitigate age-associated metabolic diseases

NAD+ supplementation could mitigate age-associated metabolic diseases

MetabolismBoosting NAD+ levels could improve cellular complications related to metabolic diseases.BWMetabolic disorders continue to increase worldwide with critical implications for the occurrence of life-threatening diseases, which include heart diseases, stroke, and cancer, all stemming from metabolic disorders. These disorders often come from obesity, which causes diabetes and high blood pressure, also called hypertension.Developing metabolic disorders relates to lifestyle choices and diet. For instance, excessive energy intake and sedentary lifestyle precipitate obesity, and metabolic...

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Jun 24
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